Research Publications

[76] dos Passos Gomes, G.; Morrison, A. E.; Dudley, G. B.; Alabugin, I. V. Optimizing amine-mediated alkyne-allene isomerization to improve benzannulation cascades: Synergy between theory and experiments. Eur. J. Org. Chem. 2019, 2/3, 512-518.

[75] El Anwar, S.; Laila, Z.; Ramsubhag, R.; Tlais, S.; Safa, A.; Dudley, G.; Naoufal, D. Synthesis and characterization of click-decahydrodecaborate derivatives by the copper (I) catalyzed [3+2] azide-alkyne cycloaddition reaction. J. Organomet. Chem. 2018, 865, 89-94.

[74] Dudley, G. B.; Stiegman, A. E. Changing perspectives on the strategic use of microwave heating in organic synthesis.  Chem. Rec. 2018, 3, 381-389.

[73] Kramer, N. J.; Hoang, T. T.; Dudley, G. B. Reaction discovery using neopentylene-tethered coupling partners: Cycloisomerization/oxidation of electron-deficient dienynes. Org. Lett. 2017, 19 4636-4639.

[72] Morrison, A. E.; Hoang, T. T.; Birepinte, M.; Dudley, G. B. Synthesis of illudinine from dimedone. Org. Lett. 2017, 19 858-861.

[71] Wu, Y.; Gagnier, J.; Dudley, G. B.; Stiegman, A. E. The “chaperone” effect in microwave-driven reactions. Chem. Commun. 2016, 52 11281-11283.

[70] Ramsubhag, R. R.; Massaro, C. L.; Dadich, C. M.; Janeczek, A. J.; Hoang, T. T.; Mazzio, E. A.; Eyunni, S.; Soliman, K. F. A.; Dudley, G. B. Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances. Org. Biomol. Chem. 2016, 14 7855-7858.

[69] Morrison, A. E.; Hrudka, J. J.; Dudley, G. B. Thermal cycloisomerization of putative allenylpyridines for the synthesis of isoquinoline derivatives. Org. Lett. 2016, 18 4104-4107.

[68] Batsomboon, P.; Dudley, G. B. Synthesis of C1-C15 of palmerolide A: tactical advances that can lead to better design strategies for polyketide synthesis. Tetrahedron Lett. 2016, 57 3757-3759.

[67] Hoang, T. T.; Birepinte, M.; Kramer, N. J.; Dudley, G. B. Six-step synthesis of alcyopterosin A, a bioactive illudalane sesquiterpene with a gem-dimethylcyclopentane ring. Org. Lett. 2016, 18 3470-3473.

[66] Slegeris, R; Dudley, G. B. Alternative synthetic approaches to rac-progesterone by way of the classic Johnson cationic polycyclization strategy. Tetrahedron 2016, 72 3666-3672.

[65] Ramsubhag, R. R.; Dudley, G. B. Orthogonal dual-click diyne for CuAAC and/or SPAAC couplings. Org. Biomol. Chem. 2016, 14 5028-5031.

[64] Wright, A. K.; Batsomboon, P.; Dai, J.; Hung, I.; Zhou, H.-X.; Dudley, G. B.; Cross, T. A. Differential binding of rimantadine enantiomers to influenza A M2 proton channel. J. Am. Chem. Soc. 2016, 138 1506-1509.

[63] Ferrari, A.; Hunt. J.; Stiegman, A. E.; Dudley, G. B. Microwave-assisted superheating and/or microwave-specific superboiling (nucleation-limited boiling) of liquids occurs under certain conditions but is mitigated by stirring.
Molecules 2015, 20 21671-21680. (Special Issue: MW-Assisted Organic Synthesis)

[62] Diaz Muñoz, G.; Dudley, G. B.Synthesis of 1,2,3,4-tetrahydroquinolines including angustureine and congeneric alkaloids. Org. Prep. Proc. Intl. 2015, 47 179-206.

[61] Dudley, G. B.; Richert, R.; Stiegman, A. E. On the existence of and mechanism for microwave-specific reaction rate enhancement. Chem. Sci. 2015, 6, 2144-2152.

[60] Rizkallah, R.; Batsomboon, P.; Dudley, G. B.; Hurt, M. The Oncogenic Kinase TOPK/PBK is a Master Mitotic Regulator of C2H2 Zinc Finger Proteins. Oncotarget 2015, 6, 1446-1461. Publicity: FSU Departments Collaborate to Identify “Master Regulator” in Cell Division and Working together to unmask “Enzyme X”

[59] Chen, P.-K.; Rosana, M. R.; Dudley, G. B.; Stiegman, A. E. Parameters affecting the microwave-specific acceleration of a chemical reaction. J. Org. Chem. 2014, 79, 7425-7436. Featured in Chemical and Engineering News and Chemistry World

[58] Rosana, M. R.; Hunt, J.; Ferrari, A.; Southworth, T.; Tao, Y.; Stiegman, A. E.; Dudley, G. B. Microwave-Specific Acceleration of a Friedel–Crafts Reaction: Evidence for Selective Heating in Homogeneous Solution. J. Org. Chem. 2014, 79, 7437-7450. Featured in Chemical and Engineering News and Chemistry World

Watch a series of video lectures on selective microwave heating by Prof Dudley:

This video series is best viewed on PC-based computers. Mac users may need to install the MicrosoftSilverlight plug-in, a link for which is available at the site. (Make sure your browser preferences are set to enable this plug-in.) A split-screen provides a synchronized broadcast of a lecture and slide show. Each part runs about 30 min.

[57] Gold, B. A.; Batsomboon, P.; Dudley, G. B.; Alabugin, I. V. Alkynyl crown ethers as a scaffold for hyperconjugative assistance in non-catalyzed azide-alkyne click reactions: ion sensing through enhanced transition state stabilization. J. Org. Chem. 2014, 79, 6221-6232.

[56] Lisboa, M. P.; Dudley, G. B. Synthesis of cytotoxic palmerolides. Chem.–Eur. J. 2013, 19, 16146-16168.

[55] Hoang, T. T.; Dudley, G. B. Synthesis of high-value 1,6-enynes by tandem fragmentation/olefination. Org. Lett. 2013, 15, 4026-4029.

[54] Dudley, G. B.; Stiegman, A. E.; Rosana, M. R. Correspondence on microwave effects in organic synthesis. Angew. Chem. Int. Ed. 2013, 52, 7918-7923.

[53] Lisboa, M. P.; Jones, D. M.; Dudley, G. B. Formal synthesis of palmerolide A, featuring alkynogenic fragmentation and syn-selective vinylogous aldol chemistry. Org. Lett. 2013, 15, 886-889.

[52] Gold, B.; Dudley, G. B.; Alabugin, I. V. Moderating strain without sacrificing reactivity: Design of fast and tunable noncatalyzed alkyne-azide cycloadditions via stereoelectronically controlled transition state stabilization. J. Am. Chem. Soc. 2013, 135, 1559-1569.

[51] Tummatorn, J.; Diaz Muñoz, G.; Dudley, G. B. Synthesis of (–)-(R)-angustureine by formal alkynylation of a chiral ß-amino ester. Tetrahedron Lett. 2013, 54, 1312-1314.

[50] Tlais, S. F.; Dudley, G. B. On the proposed structures and stereocontrolled synthesis of the cephalosporolides. Beilstein J. Org. Chem. 2012, 8, 1287-1292.

[49] Yang, J.; Wangweerawong, A.; Dudley, G. B. [1,2]-Wittig rearrangement of aromatic heterocycles. Heterocycles 2012, 85, 1603-1606.

[48] Batsomboon, P.; Gold, B. A.; Alabugin, I. V.; Dudley, G. B. Tandem nucleophilic addition/fragmentation of vinylogous acyl nonaflates for the synthesis of functionalized alkynes, with new mechanistic insight. Synthesis 2012, 44, 1818-1824. (Special Topic Issue: Tandem Reactions)

[47] Lisboa, M. P.; Jeong-Im, J. H.; Jones, D. M.; Dudley, G. B. Toward a new palmerolide assembly strategy: synthesis of C16–C24. Synlett 2012, 23, 1493-1496.

[46] Tummatorn, J.; Batsomboon, P.; Clark, R. J.; Alabugin, I. V.; Dudley, G. B. Strain-promoted azide–alkyne cycloadditions of benzocyclononynone. J. Org. Chem. 2012, 77, 2093-2097.

[45] Rosana, M. R.; Tao, Y.; Stiegman, A. E.; Dudley, G. B. On the rational design of microwave-actuated organic reactions.
Chem. Sci. 2012, 3, 1240-1244. Featured in Chemistry World and Chemical and Engineering News

[44] Gold, B.; Shevchenko, N. E.; Bonus, N.; Dudley, G. B.; Alabugin, I. V. Selective transition state stabilization via hyperconjugative assistance: stereoelectronic concept for copper-free click chemistry. J. Org. Chem. 2012, 77, 75-89.

[43] Wang, T.; Intaranukulkit; T.; Rosana, M. R.; Slegeris, R.; Simon, J.; Dudley, G. B. Microwave-assisted benzyl-transfer reactions of commercially available 2-benzyloxy-1-methylpyridinium triflate. Org. Biomol. Chem. 2012, 10, 248-250.

[42] Lisboa, M. P.; Hoang, T. T.; Dudley, G. B. Tandem nucleophilic addition / fragmentation of vinylogous acyl triflates: 2-methyl-2-(1-oxo-5-heptynyl)-1,3-dithiane. Org. Synth. 2011, 88, 353-363.

[41] Yang, J.; Tummatorn, J.; Slegeris, R.; Tlais, S. F.; Dudley, G. B. Synthesis of the tricyclic core of aldingenin B by oxidative cyclo-ketalization of an alkyne-diol. Org. Lett. 2011, 13, 2065-2067.

[40] Tlais, S. F.; Dudley, G. B. A gold-catalyzed alkyne-diol cycloisomerization for the synthesis of oxygenated 5,5-spiroketals. Beilstein J. Org. Chem. 2011, 7, 570-577.

[39] Tummatorn, J.; Dudley, G. B. Generation of medium-ring cycloalkynes by ring expansion of vinylogous acyl triflates. Org. Lett. 2011, 13, 1572-1575.

[38] Tummatorn, J.; Dudley, G. B. Stereodefined homopropargyl amines by tandem nucleophilic addition / fragmentation of dihydropyridone triflates. Org. Lett. 2011, 13, 158-160.

[37] Yang, J.; Dudley, G. B. Pyridine-directed organolithium addition to an enol ether. Adv. Synth. Catal. 2010, 352, 3438-3442.

[36] Tlais, S. F.; Dudley, G. B. Stereocontrol of 5,5-spiroketals in the synthesis of cephalosporolide H epimers. Org. Lett. 2010, 12, 4689-4701.

[35] Jones, D. M.; Dudley, G. B. An open-and-shut strategy: preparation of benzo-fused indanes by ring-opening of a vinylogous acyl triflate and metal-catalyzed Asao–Yamamoto benzannulation. Tetrahedron 2010, 66, 4860-4866. (Special Issue)

[34] Jones, D. M.; Lisboa, M. P.; Kamijo, S.; Dudley, G. B. Ring opening of cyclic vinylogous acyl triflates using stabilized carbanion nucleophiles: Claisen condensations linked to carbon–carbon bond cleavage. J. Org. Chem. 2010, 75, 3260-3267.

[33] Albiniak, P. A.; Dudley, G. B. New reagents for the synthesis of arylmethyl ethers and esters. Synlett 2010, 841-851. (Account)

[32] Jones, D. M.; Dudley, G. B. Synthesis of the C1–C15 region of palmerolide A using refined Claisen-type addition / bond cleavage methodology. Synlett 2010, 223-226.