Research Publications

2014 – present

[89] Fulo, H. F.; Shoeib, A.; Cabanlong, C. V.; Williams, A. H.; Zhan, C.-G.; Prather, P. L.; Dudley, G. B. Synthesis, Molecular Pharmacology, and Structure-Activity Relationships of 3-(Indanoyl)indoles as Selective Cannabinnoid Type 2 Receptor Antagonists. J. Med. Chem. 2021, in press.

[88] Tao, Y.; Teng, C; Musho, T. D.; van de Burgt, L.; Lochner, E.; Heller, W. T.; Strouse, G. F.; Dudley, G. B.; Stiegman, A. E. Direct Measurement of the Selective Microwave-Induced Heating of Agglomerates of Dipolar Molecules: The Origin of and Parameters Controlling a Microwave Specific Superheating Effect. J. Phys. Chem. B 2021, 125, 2146–2156.

[87] Tavakoli, A.; Dudley, G. B. Synthesis of 4,4-Dimethyl-1,6-heptadiyne and Alcyopterosin O. Org. Lett. 2020, 22, 8947–8951.

[86] Gaston, R. Jr.; Geldenhuys, W. J.; Dudley, G. B. Synthesis of Illudinine from Dimedone and Identification of Activity as a Monoamine Oxidase Inhibitor.  J. Org. Chem. 2020, 85, 13429–13437.

[85] Frasso, M. A.; Stiegman, A. E.; Dudley, G. B. Microwave-specific Acceleration of a Retro-Diels-Alder Reaction. Chem. Commun. 2020, 56, 11247–11250.

[84] Fulo, H. F.; Vincent, M. A.; Stiegman, A. E.; Dudley, G. B. Cooperative application of conventional and microwave heating. Asian J. Org. Chem. 2020, 9, 961–966.

[83] Frasso, M. A.; Stiegman, A. E.; Dudley, G. B. International perspectives on microwave heating in organic synthesis. Kagaku to Kogyo (Chemistry and Chemical Industry) 2020, 73, 244–245. (invited contribution to special issue on microwave chemistry)

[82] McCullough, B. S.; Batsomboon, P.; Hutchinson, K. B.; Dudley, G. B.; Barrios, A. M. Synthesis and PTP inhibitory activity of illudalic acid and its methyl ether, with insights into selectivity for LAR PTP over other tyrosine phosphatases under physiologically relevant conditions. J. Nat. Prod. 2019, 82, 3386–3393.

[81] Yang, J.; Guo, Y.; Wang, J.; Dudley, G. B.; Sun, K. DFT study on the reaction mechanism and regioselectivity for the [1,2]-anionic rearrangement of 2-benzyloxypyridine derivatives. Tetrahedron 2019, 75, 4451–4457.

[80] Duangkamol, C.; Batsomboon, P.; Stiegman, A. E.; Dudley, G. B. Microwave heating outperforms conventional heating for a thermal reaction that produces a thermally labile product: Observations consistent with selective microwave heating. Chem.–Asian J. 2019, 14, 2594–2597.

[79] Yang, J.; Hoang, T. T.; Dudley, G. B. Alkynogenic fragmentation. Org. Chem. Front. 2019, 6, 2560–2569.

[78] Fulo, H. F.; Albiniak, P. A.; Dudley, G. B. Discussion Addendum for Protection of Alcohols using 2-Benzyloxy-1-methylpyridinium Trifluoromethanesulfonate: Methyl (R)-(-)-3-Benzyloxy-2-methyl Propanoate. Org. Synth. 2019, 96, 124–136.

[77] Hayes, K.; Batsomboon, P.; Chen, W.-C. Becker, A.; Escherich, S.; Yang, Y.; Robart, A. R.; Dudley, G. B.; Geldenhuys, W. J.; Hazlehurst. L. A. Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460, a strategy for treatment of multiple myeloma. Bioorg. Med. Chem. 2019, 27, 1479–1488.

[76] dos Passos Gomes, G.; Morrison, A. E.; Dudley, G. B.; Alabugin, I. V. Optimizing amine-mediated alkyne-allene isomerization to improve benzannulation cascades: Synergy between theory and experiments. Eur. J. Org. Chem. 2019, 2/3, 512-518.

[75] El Anwar, S.; Laila, Z.; Ramsubhag, R.; Tlais, S.; Safa, A.; Dudley, G.; Naoufal, D. Synthesis and characterization of click-decahydrodecaborate derivatives by the copper (I) catalyzed [3+2] azide-alkyne cycloaddition reaction. J. Organomet. Chem. 2018, 865, 89-94.

[74] Dudley, G. B.; Stiegman, A. E. Changing perspectives on the strategic use of microwave heating in organic synthesis.  Chem. Rec. 2018, 3, 381-389.

[73] Kramer, N. J.; Hoang, T. T.; Dudley, G. B. Reaction discovery using neopentylene-tethered coupling partners: Cycloisomerization/oxidation of electron-deficient dienynes. Org. Lett. 2017, 19, 4636-4639.

[72] Morrison, A. E.; Hoang, T. T.; Birepinte, M.; Dudley, G. B. Synthesis of illudinine from dimedone. Org. Lett. 2017, 19, 858-861.

[71] Wu, Y.; Gagnier, J.; Dudley, G. B.; Stiegman, A. E. The “chaperone” effect in microwave-driven reactions. Chem. Commun. 2016, 52, 11281-11283.

[70] Ramsubhag, R. R.; Massaro, C. L.; Dadich, C. M.; Janeczek, A. J.; Hoang, T. T.; Mazzio, E. A.; Eyunni, S.; Soliman, K. F. A.; Dudley, G. B. Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances. Org. Biomol. Chem. 2016, 14, 7855-7858.

[69] Morrison, A. E.; Hrudka, J. J.; Dudley, G. B. Thermal cycloisomerization of putative allenylpyridines for the synthesis of isoquinoline derivatives. Org. Lett. 2016, 18, 4104-4107.

[68] Batsomboon, P.; Dudley, G. B. Synthesis of C1-C15 of palmerolide A: tactical advances that can lead to better design strategies for polyketide synthesis. Tetrahedron Lett. 2016, 57, 3757-3759.

[67] Hoang, T. T.; Birepinte, M.; Kramer, N. J.; Dudley, G. B. Six-step synthesis of alcyopterosin A, a bioactive illudalane sesquiterpene with a gem-dimethylcyclopentane ring. Org. Lett. 2016, 18, 3470-3473.

[66] Slegeris, R; Dudley, G. B. Alternative synthetic approaches to rac-progesterone by way of the classic Johnson cationic polycyclization strategy. Tetrahedron 2016, 72, 3666-3672.

[65] Ramsubhag, R. R.; Dudley, G. B. Orthogonal dual-click diyne for CuAAC and/or SPAAC couplings. Org. Biomol. Chem. 2016, 14, 5028-5031.

[64] Wright, A. K.; Batsomboon, P.; Dai, J.; Hung, I.; Zhou, H.-X.; Dudley, G. B.; Cross, T. A. Differential binding of rimantadine enantiomers to influenza A M2 proton channel. J. Am. Chem. Soc. 2016, 138, 1506-1509.

[63] Ferrari, A.; Hunt. J.; Stiegman, A. E.; Dudley, G. B. Microwave-assisted superheating and/or microwave-specific superboiling (nucleation-limited boiling) of liquids occurs under certain conditions but is mitigated by stirring.
Molecules 2015, 20, 21671-21680. (Special Issue: MW-Assisted Organic Synthesis)

[62] Diaz Muñoz, G.; Dudley, G. B.Synthesis of 1,2,3,4-tetrahydroquinolines including angustureine and congeneric alkaloids. Org. Prep. Proc. Intl. 2015, 47, 179-206.

[61] Dudley, G. B.; Richert, R.; Stiegman, A. E. On the existence of and mechanism for microwave-specific reaction rate enhancement. Chem. Sci. 2015, 6, 2144-2152.

[60] Rizkallah, R.; Batsomboon, P.; Dudley, G. B.; Hurt, M. The Oncogenic Kinase TOPK/PBK is a Master Mitotic Regulator of C2H2 Zinc Finger Proteins. Oncotarget 2015, 6, 1446-1461. Publicity: FSU Departments Collaborate to Identify “Master Regulator” in Cell Division and Working together to unmask “Enzyme X”

[59] Chen, P.-K.; Rosana, M. R.; Dudley, G. B.; Stiegman, A. E. Parameters affecting the microwave-specific acceleration of a chemical reaction. J. Org. Chem. 2014, 79, 7425-7436. Featured in Chemical and Engineering News and Chemistry World

[58] Rosana, M. R.; Hunt, J.; Ferrari, A.; Southworth, T.; Tao, Y.; Stiegman, A. E.; Dudley, G. B. Microwave-Specific Acceleration of a Friedel–Crafts Reaction: Evidence for Selective Heating in Homogeneous Solution. J. Org. Chem. 2014, 79, 7437-7450. Featured in Chemical and Engineering News and Chemistry World

Watch a series of video lectures on selective microwave heating by Prof Dudley:

This video series is best viewed on PC-based computers. Mac users may need to install the MicrosoftSilverlight plug-in, a link for which is available at the site. (Make sure your browser preferences are set to enable this plug-in.) A split-screen provides a synchronized broadcast of a lecture and slide show. Each part runs about 30 min.

[57] Gold, B. A.; Batsomboon, P.; Dudley, G. B.; Alabugin, I. V. Alkynyl crown ethers as a scaffold for hyperconjugative assistance in non-catalyzed azide-alkyne click reactions: ion sensing through enhanced transition state stabilization. J. Org. Chem. 2014, 79, 6221-6232.